Stem Cell Therapy for Rheumatoid Arthritis

Stem Cell Therapy for Rheumatoid Arthritis

 

What is Rheumatoid Arthritis?

Rheumatoid Arthritis (RA) is an autoimmune disease in which the patient’s immune system generates cellular and antibody responses to various components of the joint such as type I collagen. As a result of this immune response, not only does joint destruction occur, but also other secondary complications such as pulmonary fibrosis, renal damage, and even heart damage.

Can stem cells help treat rheumatoid arthritis?

Newly diagnosed rheumatoid arthritis is currently treated with immune suppressive agents such as steroids, methothrexate, cyclosporine, gold, and more recently infliximab (Remicade). Despite inducing temporary improvement, these approaches possess long-term adverse effects due to non-specific inhibition of immune responses. When disease-modifying anti-rheumatic drugs (DMARDs) like methotrexate are not effective, biologics like abatacept (Orencia), adalimumab (Humira) or etanercept (Enbrel) may be recommended. None of these treatments address the issue of damage that has already occurred to the joints or extra-articular tissues.

Even though advancements in rheumatoid arthritis (RA) treatment protocols and introduction of targeted biological therapies have markedly improved patient outcomes, up to 50% of patients still fail to achieve a significant clinical response.

Stem cell therapy has been demonstrated to induce profound healing activity in animals with various forms of arthritis. For example, the company Vet-Stem routinely utilizes stem cells in horses with various joint deformities to accelerate healing. Besides healing of damaged tissues, stem cells have the unique ability to modulate the immune system so as to shut off pathological responses while preserving ability to fight off disease.

Stem cells and specifically, mesenchymal stem cells (MSCs) are programed to receive signals from damaged tissue ans specifically target inflamed tissue, where they lock-on and begin producing powerful anti-inflammatory agents that stops the pain and heals the damaged tissue. These anti-inflammatory mediators act locally and do not suppress the natural immune response of the rest of the patient’s body. Additionally, MSCs induce the production of T-Regulatory Cells, a type of immune cell whose function is to protect the body against immunological self-attack.

A recent human study on MSCs for rheumatoid arthritis (Human Umbilical Cord Mesenchymal Stem Cell Therapy for Patients with Active Rheumatoid Arthritis: Safety and Efficacy) showed that MSCs produced a significant decrease in the pro-inflammatory cytokines IL-6 and TNF-α, both of which are temporarily targeted by many current RA treatments, but without the typical long-term side effects. These decreased inflammatory levels are shown in Figure 5 from the original publication.

Administration of umbilical cord tissue-derived mesenchymal stem cells, have shown improvements in rheumatoid arthritis patients markers in the blood.

 

Which types of stem cells are used to treat rheumatoid arthritis and how are they collected?

The adult stem cells used to treat RA at the Stem Cell Institute come from human umbilical cord tissue (allogeneic mesenchymal).

The mesenchymal stem cells we use are recovered from donated umbilical cords following normal, healthy births. Each mother has her medical history screened and is tested for infectious diseases. Proper consent is received from each family prior to donation.

All umbilical cord-derived stem cells are screened for infectious diseases to International Blood Bank Standards before they are cleared for use in patients.

 

What are the advantages of treating rheumatoid arthritis with allogeneic umbilical cord tissue-derived stem cells?

 

Are mesenchymal stem cells approved by the US FDA?

Human umbilical cord tissue-derived mesenchymal stem cells (MSCs) were approved by the United States FDA with the first regulation/guidelines given in November 2017. FDA Commissioner, Scott Gottlieb, MD, has said, “We’re at the beginning of a paradigm change in medicine with the promise of being able to facilitate regeneration of parts of the human body and adult stem cells can generate replacements for cells that are lost to injury or disease. This is no longer the stuff of science fiction. This is the practical promise of modern applications of regenerative medicine.” 

 

How are the stem cells administered for rheumatoid arthritis treatment?

Stem Cells are given by intravenous (IV) infusion over a period of 15 to 30 minutes. Typically each patient receives 60-90 Million Cells per infusion.

 

For More Information about Stem Cell Therapy

For more detailed information about Stem Cell Therapy for Rheumatoid Arthritis, we encourage you to read/download the entire chapter on stem cell therapy for arthritis from Dr. Niel Riordan’s new book, Stem Cell Therapy: A Rising Tide – How Stem Cells are Disrupting Medicine and Transforming Lives.  Click here (FREE PDF)

 

“Neil takes readers on a riveting journey through the past, present and future of stem cell therapy. His well-researched, educational and entertaining book could change your life. I highly recommend it.” – Tony Robbins, NY Times #1 Bestselling Author

“100 years old will soon become the new 60. Stem cells are a key therapeutic to enable this future. Dr. Riordan’s book is your guide to why this is true and how you will benefit. A must read for anyone who cares about extending their healthy lifespan.” – Peter H. Diamandis, MD; Founder, XPRIZE & Singularity University; Co-Founder, Human Longevity, Inc.; Author of NY Times Best Sellers Abundance and Bold

 

 

Research

 

 

Author
Dr. Clark H. Hansen Dr. Clark H. Hansen is a licensed Naturopathic Medical Doctor (N.M.D.) who has been in private practice in Scottsdale, Arizona, since 1986. He is the President and Medical Director of the Hansen Clinic of Natural Medicine, Aesthetics and Mesotherapy. Dr. Hansen is one of the most well respected Naturopathic Physicians in the country and a Diplomat of the World Society of Anti-Aging Medicine.

You Might Also Enjoy...

Stem Cell Therapy Overview - Regenerate a New You!

Stem Cells are the body's Restore or Replace secret weapon. They can change into any type of cell that the body needs to supplement, restore, reconstruct or replace damaged cells, including Joints, Bones, Heart, Muscle, Nerves, Organs & Skin.

Stem Cell Therapy for STROKE Recovery

Stem Cell Therapy for Strokes may revolutionize how we treat not only stroke, but traumatic brain injury and even neurodegenerative disorders. The notion that once the brain is injured, it doesn't recover, has now been proven false.

Top Ten Reasons NOT to have Total Knee Replacement Surgery

It is estimated that at least 27 million people are affected by arthritis in the US, with an estimated total annual cost of $89.1 billion dollars. If you are considering a $50,000 Total Knee Replacement Surgery don't do it without considering the risks.

Stem Cell Therapy for Lupus

Human Umbilical Cord Tissue is perhaps the greatest discovery and offers the highest hope for healing Systemic Lupus Erythematosus.

Stem Cell Therapy for COPD

Today more than 600 million people suffer from chronic obstructive pulmonary disease (COPD) worldwide. Although there is no cure for COPD, recent advancements in cellular therapy have made it possible to not only relieve symptoms, but to promote healing.